Guanidine Thiocyanate (25072)

Guanidine thiocyanate irreversibly inhibits catalytic activity of nucleases DNase and RNase thus preventing them from degrading nucleic acids during cell lysis. 

Guanidine thiocyanate also has the added benefit of being a chaotropic agent. This feature allows it to decrease the action of hydrogen bonds in water as well as disrupts intramolecular interactions within proteins and other macromolecules – further increasing solubility of unwanted cellular components.

Assay: ≥99.5%

Key Applications: DNA and RNA extraction