Dimethyldioctadecylammonium bromide (DDAB) is a synthetic amphiphilic cationic lipid commonly used in vaccine development and gene delivery due to its ability to self-assemble into vesicular bilayers that mimic phospholipid liposomes. These structures enable efficient encapsulation and delivery of antigens or genetic material, promoting strong cell-mediated and humoral immune responses. Due to their susceptibility to membrane instability under stress conditions, DDAB-based vesicles are commonly formulated with Trehalose-6,6-dibehenate (TDB), a glycolipid with shorter fatty acid chains that reinforces bilayer stability and promotes hydration. Beyond immunology, DDAB’s strong electrostatic interaction with DNA and RNA makes it valuable in forming cationic liposomes for gene transfection and drug delivery, though its potential cytotoxicity requires careful formulation.
| CAS Number | 3700-67-2 |
|---|---|
| Store At Temperature | -20°C |
| Shipping Condition | Dry ice |
Dimethyldioctadecylammonium bromide (DDAB) is a synthetic amphiphilic cationic lipid commonly used in vaccine development and gene delivery due to its ability to self-assemble into vesicular bilayers that mimic phospholipid liposomes. These structures enable efficient encapsulation and delivery of antigens or genetic material, promoting strong cell-mediated and humoral immune responses. Due to their susceptibility to membrane instability under stress conditions, DDAB-based vesicles are commonly formulated with Trehalose-6,6-dibehenate (TDB), a glycolipid with shorter fatty acid chains that reinforces bilayer stability and promotes hydration. Beyond immunology, DDAB’s strong electrostatic interaction with DNA and RNA makes it valuable in forming cationic liposomes for gene transfection and drug delivery, though its potential cytotoxicity requires careful formulation.
| CAS Number | 3700-67-2 |
|---|---|
| Store At Temperature | -20°C |
| Shipping Condition | Dry ice |