DODAP (1,2-dioleoyl-3-dimethylammonium-propane) is an ionizable lipid with low cytotoxicity and high cellular uptake efficiency. DODAP is neutral at physiological pH, but acquires a positive charge at low pH, such as the inside of endosomes due to the protonation of free amines when pH is lower than its pKa. The electrostatic interactions between DODAP and naturally occurring anionic lipids in endosomal membranes trigger the release of nucleic acid. DODAP is often used in the formulation of nanocarriers (LNPs, lipid-polymer hybrid nanoparticles) used to encapsulate bioactive molecules, including mRNA, RNA, and plasmid DNA.
| CAS Number | 127512-29-2 |
|---|---|
| Store At Temperature | -20°C |
| Shipping Condition | Dry ice |
DODAP (1,2-dioleoyl-3-dimethylammonium-propane) is an ionizable lipid with low cytotoxicity and high cellular uptake efficiency. DODAP is neutral at physiological pH, but acquires a positive charge at low pH, such as the inside of endosomes due to the protonation of free amines when pH is lower than its pKa. The electrostatic interactions between DODAP and naturally occurring anionic lipids in endosomal membranes trigger the release of nucleic acid. DODAP is often used in the formulation of nanocarriers (LNPs, lipid-polymer hybrid nanoparticles) used to encapsulate bioactive molecules, including mRNA, RNA, and plasmid DNA.
| CAS Number | 127512-29-2 |
|---|---|
| Store At Temperature | -20°C |
| Shipping Condition | Dry ice |