DODAP (14489)


Size: 100 mg
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Sale price$210.00
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Description

DODAP (1,2-dioleoyl-3-dimethylammonium-propane) is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7). The electrostatic interactions between DODAP and naturally occurring anionic lipids in endosomal membranes trigger the release of nucleic acid. These interactions promote membrane lytic non-bilayer structures to enable the intracellular delivery of nucleic acid. A common application is in nanomedicine as an ionizable lipid component of nanocarriers (lipid-polymer hybrid nanoparticles, LPNs), widely used to encapsulate bioactive molecules, including mRNA, siRNA, and plasmid DNA as a treatment for diseases. 

  • Efficient delivery of plasmid DNA, siRNA/miRNA, and CRISPR/Cas9 components
  • Widely used in nanomedicine
  • Flexible and scalable
Catalog No. 14489
CAS No. 127512-29-2
Linear Formula C41H77NO4
Appearance Colorless to light yellow liquid
Molecular Weight 648.05 g/mol
Shipping & Handling Requirements Dry ice
Store At -20°C
Download Safety Data Sheet

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