DOTAP Methyl Sulfate (14475-MS)

Size: 100 mg
Sale price$149.00
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DOTAP MS (N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate) is a proven reagent for the highly efficient liposomal transfection of DNA, RNA, oligonucleotides, and some other negatively charged large biomolecules. Several other techniques of introducing genetic material into cells may suffer from inadequate reproducibility, cytotoxicity, inconvenience of process, and low transfection efficiency. DOTAP avoids these drawbacks and works by encapsulating the negatively charged DNA within a spontaneously formed liposomal vesicle. This DOTAP/DNA complex can then fuse with the cell membrane and insert DNA directly into the cytoplasm. This mechanism of action ensures transfection occurs efficiently and with little to no cytotoxicity. 

  • Non-cytotoxic at working concentrations
  • High efficiency and reproducibility
  • Cost effective and easy to use
Catalog No. 14475
CAS No. 144189-73-1
Linear Formula C43H83NO8S
Appearance White solid
Molecular Weight 774.21 g/mol
Solubility Ethanol, chloroform, DMSO, DMF
Insoluble in Water
Store At -20°C (Powder), 4°C (Formulated Solution)
Download Safety Data Sheet

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